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Table of Contents

BLOOD COMMENTARIES

REVIEW ARTICLES

These 2 reviews respectively examine the value and utility of geriatric assessment (GA) tools and discuss the role of GA in the clinical management of patients with hematologic malignancies.

These 2 reviews respectively examine the value and utility of geriatric assessment (GA) tools and discuss the role of GA in the clinical management of patients with hematologic malignancies.

HOW I TREAT

In this How I Treat article on Waldenström macroglobulinemia, the authors present different case-based clinical scenarios and discuss available treatment options.

CLINICAL TRIALS AND OBSERVATIONS

LYMPHOID NEOPLASIA

This article describes the interplay between the serine/threonine kinase maternal embryonic leucine zipper kinase (MELK) and the enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) and provides a basis for targeting this enzymatic pathway in mature natural killer/T-cell malignancies.

The authors provide a topological analysis using multiplex immunofluorescence microscopy to highlight the role of CTLA-4 in the tumor microenvironment of classical Hodgkin lymphoma.

PLATELETS AND THROMBOPOIESIS

The authors provide evidence of a novel association between transcription factor IKZF5, one of the IKAROS family proteins, and thrombocytopenia with decreased alpha granules, thus significantly extending our understanding of the gene defects leading to inherited thrombocytopenia.

THROMBOSIS AND HEMOSTASIS

This paper reports on the use of a high-throughput diagnostic genetic screening for coagulation, platelet, or thrombotic disorders in a series of more than 2000 patients.

TRANSPLANTATION

LETTERS TO BLOOD

BLOOD WORK

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