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BLOOD COMMENTARIES

The bone marrow niche environment is essential for the control and maintenance of hematopoietic stem cells (HSCs). The investigators present the first global analysis of the communication between distinct niche cell types and HSCs.

REVIEW ARTICLE

This review article summarizes the clinical outcomes and genotoxicity issues of gene therapy for hemoglobinopathies based on lentiviral vectors carrying a β-globin–like gene or genome editing to correct the erythropoietic defect.

HEMATOPOIESIS AND STEM CELLS

The bone marrow niche environment is essential for the control and maintenance of hematopoietic stem cells (HSCs). The investigators present the first global analysis of the communication between distinct niche cell types and HSCs.

LYMPHOID NEOPLASIA

The authors report the interaction between Down syndrome, a major genetic leukemia predisposition condition, and inherited genetic alleles associated with increased susceptibility to childhood acute lymphoblastic leukemia.

The investigators present results on the long-term value and limitations of early interim positron emission tomography (PET) scanning in advanced Hodgkin lymphoma.

BLOOD WORK

ERRATUM

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