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Hematology is a diverse medical specialty requiring highly trained and experienced practitioners. Further, with advancing knowledge and the aging of the population, it is expected that the need will outpace the availability of trained hematologists. Sharma and colleagues explore the trends and factors affecting the adult hematology workforce in an article with important implications.
The pan-PIM inhibitor INCB053914 displays potent synergy in combination with ruxolitinib in models of MPN
Myeloproliferative neoplasms (MPNs) are driven by aberrant signaling of JAK2 tyrosine kinases. Although JAK2 inhibitors have been demonstrated to be useful in the treatment of these disorders, they have many well-described limitations. Reuther and colleagues used a pan-PIM inhibitor and reached interesting findings with potential clinical relevance.
Patients with FLT3+ acute myeloid leukemia are known to be high risk that is modulated somewhat by specific inhibitors. However, relapse is still relatively common. Beeharry and colleagues explored a novel heat shock protein 90 inhibitor, LAM-003, with interesting results that could lead to clinical translation.
Patients with immune thrombocytopenia often have been found to have serologic markers of autoimmunity that has been suggested to result in worse outcomes. Kuter and colleagues evaluated this question and reach interesting clinical findings.
Results from a multidisciplinary clinic guided by geriatric assessment before stem cell transplantation in older adults
A major advance in the field of hematopoietic cell transplantation is the ability to treat older patients who more frequently develop diseases effectively treated with transplantation. However, it is well recognized that these aggressive treatments can be challenging. Artz and colleagues explored the utility of an organized approach through a multidisciplinary clinic guided by a geriatric assessment to better manage older patients that may serve as a model to improve outcomes for this challenging patient population.
Human ectoenzyme-expressing ILC3: immunosuppressive innate cells that are depleted in graft versus host disease
Innate lymphoid cells are known to play essential roles in intestinal homeostasis and produce cytokines that may promote healing, for example, in the setting of graft-versus-host disease (GVHD) injury to the gastrointestinal tract. Shikhagaie and colleagues explored the role of a population of ectoenzyme-expressing ILC3 cells in the setting of GVHD.